Figure 5.

Minor groove hydration pattern in f/rA2U2-P3 (three duplexes per asymmetric unit). 2′-F-RNA and RNA residues are highlighted in green and red, respectively, and water molecules are highlighted in blue. Hydrogen bonds (≤3.3 Å distance between potential acceptor and donor atoms) are indicated with thin solid lines, with distances given in Å. Distances below 3.3 Å between fluorine atoms and water are highlighted in green and van der Waals contacts between fluorine atoms are dashed and green. Please note the typically much longer distances (dashed lines in black) between 2′-fluorine atoms and water molecules compared with distances between 2′-OH groups and water.