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Distance distribution for water interactions in the minor grooves of fully 2′-F-modified RNA (fA2U2) and mixed 2′-F/-OH RNA (f/rA2U2-P3 and f/rA2U2-R32) duplexes. Color code: green, 2′-F···H2O; red, 2′-OH···H2O and pink, O2(C,U)/ N3(G,A)···H2O.
