Table 2.
Summarizing expression status of PIG-U/PIG-T/GPAA1/GPI8/PIG-S protein among most common cancer types and corresponding normal tissuesa
| Tissue | PIG-U
|
PIG-T
|
GPAA1
|
GPI-8
|
PIG-S
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| +++ (%) | ++ (%) | + (%) | −ve(%)/P** | +++ (%) | ++ (%) | + (%) | −ve (%)/P | +++ (%) | ++ (%) | + (%) | −ve (%)/P | +++ (%) | ++ (%) | + (%) | −ve (%)/P | +++ (%) | ++ (%) | + (%) | −ve (%)/P | |
| Stomach (T) | 65 | 30 | 5 | — | 6 | 72 | 22 | — | 50 | 40 | — | 10 | — | 26 | 58 | 16 | — | 55 | 15 | 30 |
| Stomach (N) | 25 | 75 | — | — | 100 | — | — | — | — | 100 | — | — | — | 100 | — | — | 25% | 75 | — | — |
| Skin (T) | 31 | 59 | 10 | — | — | 68 | 32 | — | 11 | 57 | 25 | 7 | — | 7 | 61 | 32 | — | 34 | 52 | 14 |
| Skin (N) | — | 100 | — | — | — | 100 | — | — | 40 | 40 | 20 | — | — | — | 100 | — | — | 20 | 80 | — |
| Prostate (T) | 35 | 41 | 24 | — | 6 | 82 | 12 | — | 6 | 35 | 47 | 12 | — | 18 | 53 | 29 | — | 24 | 24 | 52 |
| Prostate (N) | — | 50 | 50 | — | — | 50 | 50 | — | — | — | 50 | 50 | — | — | 50 | 50 | — | 100 | — | — |
| Ovary (T) | 55 | 35 | 10 | — | 7 | 50 | 43 | — | 15 | 45 | 30 | 10 | 10 | 54 | 33 | 3 | — | 69 | 28 | 3 |
| Ovary (N) | — | 40 | 60 | —/P =0.007 | — | 20 | 40 | 40 | — | — | 60 | 40/P =0.011 | — | — | 50 | 50/P =0.015 | — | 80 | 20 | — |
| Breast (T) | 30 | 59 | 7 | 4 | 50 | 43 | 7 | — | 19 | 39 | 26 | 16 | 3 | 38 | 38 | 21 | — | 80 | 20 | — |
| Breast (N) | 11 | 33 | 23 | 33/P =0.005 | — | 89 | 11 | — | 44 | — | 44 | 12 | — | 11 | 33 | 56 | — | 50 | 50 | — |
| Testis (T) | — | 63 | 37 | — | 24 | 70 | 6 | — | — | 32 | 53 | 15 | 5 | 17 | 67 | 11 | — | 22 | 78 | — |
| Testis (N) | — | 50 | 50 | — | — | 100 | — | — | — | — | 100 | — | — | 50 | 50 | — | — | 50 | 50 | — |
| Colon (T) | 50 | 33 | 17 | — | 12 | 76 | 12 | — | 18 | 47 | 35 | — | 11 | 53 | 36 | — | 5 | 90 | 5 | — |
| Colon (N) | 20 | 80 | — | — | — | 20 | 80 | —/ | ||||||||||||
| P =0.003 | — | 100 | — | — | 40 | 60 | — | —/P<0.001 | — | 100 | — | — | ||||||||
| Bladder (T) | 5 | 58 | 37 | — | 18 | 53 | 29 | — | — | 44 | 50 | 6 | — | 5 | 69 | 26 | — | 94 | 6 | — |
| Bladder (N) | — | 67 | 33 | — | — | 75 | — | 25 | — | 25 | 75 | — | — | — | 75 | 25/P<0.001 | — | 75 | 25 | — |
| Uterus (T) | 70 | 30 | — | — | — | 40 | 40 | 20 | 10 | 65 | 25 | — | 11 | 56 | 33 | — | 70 | 20 | 10 | — |
| Uterus (N) | 20 | 80 | — | — | — | — | 100 | — | 20 | 20 | 60 | — | — | — | 100 | —/P =0.015 | 60 | 40 | — | — |
| Thyroid (T) | 45 | 50 | 5 | — | 45 | 55 | — | — | 25 | 40 | 30 | 5 | 40 | 5 | 45 | 10 | 5 | 60 | 35 | — |
| Thyroid (N) | — | 60 | 40 | — | — | 40 | 60 | —/P =0.001 | — | — | 80 | 20/P =0.009 | — | 20 | 80 | — | — | — | 100 | —/P =0.001 |
| Lung (T) | 10 | 40 | 50 | — | 13 | 73 | 10 | 4 | 3 | 37 | 50 | 10 | — | 10 | 87 | 3 | — | 30 | 70 | — |
| Lung (N | — | 75 | 25 | — | — | — | 100 | —/P =0.001 | — | — | 80 | 20 | — | — | 20 | 80 | — | — | 100 | — |
| Lymph node (T) | — | 37 | 53 | 10 | — | 15 | 75 | 10 | — | 10 | 50 | 40 | — | 5 | 60 | 35 | — | 16 | 84 | — |
| Lymph node (N) | — | — | — | 100/ | ||||||||||||||||
| P<0.001 | — | — | 100 | — | — | — | 67 | 33 | — | — | — | 100/P<0.001 | — | 11 | 89 | — | ||||
| Liver (T) | 11 | 84 | 5 | — | 26 | 74 | — | — | — | 74 | 26 | — | 11 | 21 | 68 | — | — | 65 | 35 | — |
| Liver (N) | 20 | 80 | — | — | — | 100 | — | — | — | 100 | — | — | — | 75 | 25 | —/P<0.001 | — | 60 | — | 40 |
| Pancreas (T) | 5 | 90 | 5 | — | 25 | 65 | 10 | — | 5 | 55 | 35 | 5 | — | 5 | 80 | 15 | 10 | 75 | 15 | — |
| Pancreas (N | — | 100 | — | — | 20 | — | 80 | —/P =0.001 | — | 80 | — | 20 | — | 100 | — | — | — | 60 | 20 | 20 |
| Kidney (T) | 16 | 53 | 31 | — | 44 | 37 | 19 | — | 5 | 32 | 47 | 16 | 5 | 5 | 75 | 15 | 10 | 53 | 37 | — |
| Kidney (N) | — | 100 | — | — | 100 | — | — | — | 100 | — | — | — | 100 | — | — | — | 20 | 60 | — | 20 |
The intensity of immunostaining was scored as follows: (−ve), no detectable immunostaining or basal immunostaining in <10% cells; (+), mild immunostaining in 10–30% cells; (++), moderate immunostaining in 30–50% cells and (+++), intense immunostaining in >50% of the cells showing cytoplasmic staining.
P indicates statistical significance of expression when <0.05.