Table 6.
A fraction of Gcn5flox(neo)/Δ embryos exhibit NTDs
| Number of offspring of each Gcn5 genotype1 | ||||||
|---|---|---|---|---|---|---|
| Age | +/+ | flox(neo)/+ | +/Δ | flox (neo)/Δ | Total number |
|
| total | NTD (%) | |||||
| E9.5 | 69 | 76 | 71 | 72 | 28 (39%) | 288 |
| E10.5 | 532 | 50 | 53 | 50 | 21 (42%) | 206 |
| E11.5 | 15 | 163 | 13 | 12 | 6 (50%) | 56 |
| E12.5 | 5 | 5 | 6 | 4 | 2 (50%) | 20 |
| E13.5 | 10 | 11 | 9 | 8 | 4 (50%) | 38 |
| E15.5 | 10 | 12 | 10 | 10 | 5 (50%) | 42 |
| E18.5 | 20 | 21 | 22 | 26 | 11 (42%) | 89 |
| E18.5 (129SvEv) | 14 | 13 | 16 | 12 | 12 (100%)* | 55 |
| E18.5 (BL6) | 16 | 14 | 15 | 16 | 3 (19%)* | 61 |
1
Progeny of crosses between Gcn5+/Δ and Gcn5flox(neo)/+ mice observed at the indicated time points. Observed numbers are close the to expected occurrence of 25% for each of the resulting genotypes.
2
One of these 53 embryos (1.9%) exhibited a neural tube defect (NTD).
3
One of these 16 embryos (6.3%) exhibited a neural tube defect (NTD).
*
p=0.000015, Fisher’s exact test