Figure 1.

Longitudinal in vivo carbon 11–labeled Pittsburgh Compound B ([¹¹C]PiB) imaging in an older adult with cognitive decline. A, Informant Clinical Dementia Rating (CDR) scores before and during in vivo β-amyloid imaging. The shaded area shows CDR data at the time of the [¹¹C]PiB studies shown in part B. B, Surface projections and parasagittal [¹¹C]PiB images during the participant’s cognitive decline. Consensus diagnoses and mean cortical distribution volume ratios (cDVRs) are noted below the images. Neuropathologic findings for this individual are shown in Figure 4F. CDR-SB indicates CDR Sum of Boxes.