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Effect of erastin and erastin A8 on NADH transport through hVDAC2. (a) Structure of erastin and its inactive analogue, erastin A8. (b) hVDAC2-containing liposomes visualized by CryoEM. (c) Relative NADH oxidation rates in wild-type VDAC2-containing liposomes, normalized to oxidation rates observed with DMSO treatment. (d) Relative NADH oxidation rates in N-terminal-truncated VDAC2-containing liposomes, normalized to oxidation rates observed with DMSO treatment.
