Table 3.
Multivariate Cox Regression Analysis Demonstrates Intratumoral CD8 Score Is an Independent Predictor of Merkel Cell Carcinoma Outcome
| Characteristic | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Stage | ||||||
| II v I | 0.8 | 0.1 to 5.0 | .86 | 1.1 | 0.2 to 6.6 | .92 |
| III v I | 6.5 | 1.9 to 22.6 | < .01 | 5.5 | 1.4 to 21.2 | .02 |
| IV v I | 18.8 | 3.4 to 104.5 | < .01 | 31.5 | 6.8 to 147.0 | < .01 |
| Female sex | 0.4 | 0.1 to 1.0 | .06 | 0.6 | 0.2 to 1.7 | .31 |
| Age at diagnosis ≥ 65 years | 1.1 | 0.5 to 2.3 | .87 | 0.8 | 0.4 to 1.8 | .62 |
| CD8, per increase on 0 to 5 scale | ||||||
| Peritumoral | 0.8 | 0.6 to 1.0 | .06 | 0.9 | 0.6 to 1.4 | .79 |
| Intratumoral | 0.5 | 0.5 to 0.7 | < .01 | 0.5 | 0.3 to 0.9 | .01 |
NOTE. CD8+ scoring scale is described in Methods and in the scoring guide provided as a Data Supplement. All variables listed in this table were included in the multivariate analysis.
Abbreviation: HR, hazard ratio.