Table 1.

Clinicohistologic Characteristics of Individual NMF Subgroups and of the Overall Study Cohort

Variable	NMF Subgroup						Overall(N = 189)
	c1: MYC (n = 29)	c2: Neuronal (n = 37)	c3: SHH (n = 52)	c4: Mixed (n = 34)	c5: Photoreceptor (n = 23)	c6: WNT (n = 14)
% of overall patients	15.34	19.58	27.51	17.99	12.17	7.40
Sex, No.
Male	23	25	25	21	16	3	113
Female	6	12	27	13	7	10	75
Male-to-female ratio	3.83	2.08	0.93	1.61	2.29	0.3	1.51
Age, months
Median	64	103	67	84	64	96	79
Range	7-178	48-227	11-527	12-264	12-144	48-159	7-527
Age group by years, %
< 3	25	0	34*	14.71	21.74	0	18.09
3-7	42.86	37.14	22	41.48	56.52	30.77	35.64
7-12	17.86	51.43	20	23.53	21.74	53.85	28.19
12-18	14.29	8.57	16	17.65	0	15.38	12.23
18-25	0	2.86	2	2.94	0	0	1.60
> 25	0	0	6	0	0	0	1.60
Histologic subtype, %
Classic	73	85.7	51	79.4	61.9	85.71	71
Nodular/desmoplastic	4	11.4	38.3*	8.8	4.76	0	15.3
Large cell/anaplastic	23	2.86	10.6	11.8	33.33	7.1	13.6
M+ disease
No.	7	4	8	4	0	1	24
No. evaluated	25	30	42	31	21	12	163
%	28	13.33	18.18	12.90	0	8.33	14.72
Relapse-free survival, %†	21.01	51.94	57.65	76.35	68.38	81.82	60.56
Overall survival, %†	21.01‡	87.67	64.99	95	74.07	90.91	73.57

Abbreviations: NMF, non-negative matrix factorization; SHH, Sonic Hedgehog.

^*Statistically significant P value (< .05) for association of subgroup v all other subgroups.

^†Kaplan-Meier adjusted 6-year survival (EFS and OS) for patients greater than 36 months of age.

^‡Statistically significant difference between survival curves for subgroup patients v all other patients (log-rank test).