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. Author manuscript; available in PMC: 2011 Apr 27.
Published in final edited form as: Tetrahedron Lett. 2009 Oct 21;50(42):5780–5782. doi: 10.1016/j.tetlet.2009.07.079

Table 1.

Synthesis of 2-oxazolines 4b from carboxylic acids 1 using open vessel mode microwave heating

Entry Acid Oxazoline product Reaction conditions % Yield
1 graphic file with name nihms-278038-t0002.jpg graphic file with name nihms-278038-t0003.jpg 170 °C, 15 min 85
2 graphic file with name nihms-278038-t0004.jpg graphic file with name nihms-278038-t0005.jpg 170 °C, 15 min 78
3 graphic file with name nihms-278038-t0006.jpg graphic file with name nihms-278038-t0007.jpg 170 °C, 15 min 79
4 graphic file with name nihms-278038-t0008.jpg graphic file with name nihms-278038-t0009.jpg 170 °C, 15 min 83
5 graphic file with name nihms-278038-t0010.jpg graphic file with name nihms-278038-t0011.jpg 170 °C, 15 min 81
6 graphic file with name nihms-278038-t0012.jpg graphic file with name nihms-278038-t0013.jpg 170 °C, 15 min 73
7 graphic file with name nihms-278038-t0014.jpg graphic file with name nihms-278038-t0015.jpg 170 °C, 15 min 71
8 graphic file with name nihms-278038-t0016.jpg graphic file with name nihms-278038-t0017.jpg 170 °C, 15 min 80
9 graphic file with name nihms-278038-t0018.jpg graphic file with name nihms-278038-t0019.jpg 170 °C, 25 min 78
10 graphic file with name nihms-278038-t0020.jpg graphic file with name nihms-278038-t0021.jpg 170 °C, 25 min 82
11 graphic file with name nihms-278038-t0022.jpg graphic file with name nihms-278038-t0023.jpg 170 °C, 40 min 73
12 graphic file with name nihms-278038-t0024.jpg graphic file with name nihms-278038-t0025.jpg 170 °C, 25 min 78