Table 3.
Average Numerical Density (n/mm2) of RD3-positive Intracellular Neurofibrillary Tangles and Ghost Tangles in Down Syndrome and Alzheimer Disease Subjects
| NFT Type |
Group | EC II L |
EC III-VI L |
CA1 | CA4 | Amygdala | Temporal Cortex |
Frontal Cortex |
Occipital Cortex |
|---|---|---|---|---|---|---|---|---|---|
| Intra- cellular NFTs |
DS | 92 (13.2) p < 0.0001 |
117.1 (10.3) p < 0.0001 |
136.4 (7.3) p < 0.003 |
61.0 (5.2) p < 0.0001 |
167.9 (4.3) p < 0.0001 |
120.6 (4.4) p < 0.0001 |
94.1 (3.6) p < 0.0001 |
58.4 (3.2) p < 0.0001 |
| AD | 37 (6.7) |
73 (7.4) |
110.2 (5.2) |
19.7 (2.4) |
70.9 (3.0) |
78.8 (2.9) |
25.3 (1.8) |
27.7 (2.3) |
|
| Ratio of DS:AD |
2.5 | 1.6 | 1.2 | 3.0 | 2.4 | 1.5 | 3.7 | 2.1 | |
| Ghost tangles |
DS | 439 (27.2) p < 0.05 |
179 (13.8) p < 0.02 |
68.0 (5.9) p < 0.0001 |
52.3 (5.0) p < 0.0001 |
40.5 (2.0) p < 0.0001 |
37.9 (2.3) p < 0.0001 |
24.7 (1.6) p < 0.0001) |
1.7 (0.5) p < 0.002 |
| AD | 509.1 (22.8) |
225 (14.3) |
106.0 (8.0) |
27.3 (3.2) |
70.0 (3.5) |
17.2 (1.4) |
1.4 (0.4) |
0.1 (0.0) |
|
| Ratio of DS:AD |
0.9 | 0.8 | 0.6 | 1.9 | 0.6 | 2.2 | 17.6 | 17 |
12 Down Syndrome (DS) and 14 sporadic Alzheimer disease (AD) cases were evaluated; EC, entorhinal cortex; CA, cornu Ammonis; L = layer; NFT = neurofibrillary tangle; p values in the DS rows are vs. AD. Numbers in parentheses are SD.