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. 2011 May;21(5):798–810. doi: 10.1101/gr.111385.110

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Copyright © 2011 by Cold Spring Harbor Laboratory Press

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Figure 4. — miRNA programs underlie the stem to progenitor transition. Multi-factorial analyses revealed various miRNA programs that control the transitions from blood and muscle stem cells (LT-HSCs and MuSCs) to the corresponding immediate differentiating progenies (KSL cells and myoblasts, respectively). (A) The comparisons performed in multi-factorial analyses to yield functional miRNA groups identified. (B) miRNAs discordantly regulated during stem to progenitor transition in blood and muscle. (C,D) miRNAs concordantly regulated during stem to progenitor transition but more drastically regulated in either muscle (C) or blood (D). (E) miRNAs concordantly regulated during stem to progenitor transition in blood and muscle.