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. 2011 May;337(2):479–486. doi: 10.1124/jpet.110.177824

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Copyright © 2011 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 2. — Proteasome inhibition in tumor cells by LG and NLG analogs. RPMI 8226 (A) and PC-3 (B) cells were incubated with various concentrations of LG [marizomib (NPI-0052), NPI-2150, NPI-2151; filled symbols] or NLG (NPI-0047, NPI-2063, NPI-2080; open symbols) analogs for 1 h. Percentage of inhibition of CT-L activity was calculated relative to the amount of proteasome activity in cells exposed to the DMSO vehicle only. The results represent the means ± S.D. of three independent experiments, except for NPI-2150 and NPI-2151 in PC-3 for which the average of two independent experiments is shown.