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Cytotoxicity of LG and NLG analogs against RPMI 8226 and PC-3 cells
| Compound | R | IC50 Value ± S.D. |
|
|---|---|---|---|
| RPMI 8226 | PC-3 | ||
| nM | |||
| Marizomib (NPI-0052) | CH2CH2Cl | 10 ± 3 | 35 ± 9 |
| NPI-2150 | CH2CH2OMesyl | 144 ± 46 | 203 ± 46 |
| NPI-2151 | CH2CH2OTosyl | 27 ± 9 | 54 ± 10 |
| NPI-0047 | Ethyl | 20,000 ± 4000 | 16,000 ± 3000 |
| NPI-2063 | Methyl | 8500 ± 3000 | 28,000 ± 14,000 |
| NPI-2080 | Propyl | 6300 ± 3000 | 15,000 ± 3000 |
