TABLE 1.
Hepatic clearance and extraction ratio of prodrugs in rat isolated perfused livers
| Prodrug | Hepatic Clearance |
EH | ||
|---|---|---|---|---|
| Total | Metabolic | Biliary | ||
| ml/min | ||||
| Pafuramidine | 17.6 | 17.6 | <0.1 | 0.88 |
| CPD-0868 | 12.4 | 12.4 | <0.1 | 0.62 |
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