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. 2011 May;337(2):487–493. doi: 10.1124/jpet.111.179317

Fig. 2.

Fig. 2.

Experiment 2: 100 mg/kg NAC during extinction. A, time course for experiment 2. NAC (100 mg/kg) treatment occurred during daily extinction sessions and on cue and cue + cocaine-primed reinstatement testing. Rats were retested after 2 weeks of abstinence without NAC. B, active lever presses during the last 3 days of self-administration. C, lever responding over the 12 days of extinction (main effect of group, p < 0.05). D, reinstatement of cocaine seeking by cues or cues + cocaine. *, reduced responding by NAC treatment relative to saline treatment; p < 0.05. E, cocaine seeking at 2 weeks after discontinuation of NAC treatment. *, reduced responding by NAC treatment relative to saline treatment; p < 0.05. Sal, saline; VEH, vehicle.