Fig. 4.

Experiment 4: 100 mg/kg NAC during abstinence. A, time course for experiment 4. NAC (100 mg/kg) treatment occurred daily during abstinence, but not on tests or during extinction. Rats were tested for context relapse and went through subsequent extinction and reinstatement testing. B, active lever presses during the last 3 days of self-administration. C, relapse to the cocaine context after abstinence. *, reduced responding by NAC treatment relative to saline treatment; p < 0.05. D, lever responding over the 11 days of extinction. E, reinstatement of cocaine seeking by cues or cocaine. Sal, saline; VEH, vehicle.