Fig. 2a, b, c.

Rotenone influences the P2X7 receptor current densities in a time- and concentration-dependent way. a Sample traces of inward currents induced by 300 μM BzATP in astrocytes after treatment with 0, 2, 20 or 200 nM rotenone for 24 or 48 h. Numbers in parentheses represent the membrane capacitance of astrocytes investigated. b Histogram of P2X7 receptor current densities after different treatments. *P_{200 vs. 0 nM, 24 h} < 0.05, n = 18. ^†P_{2 vs. 0 nM, 48 h} < 0.05, n = 16. ^‡P_{20 vs. 0 nM, 48 h} < 0.01, n = 16. ^§P_{200 vs. 0 nM, 48 h} < 0.05, n = 15. ^¶P_{20 vs. 2 nM, 48 h} < 0.05, n = 16. ^‖P_{0 nM, 48 vs. 24 h} < 0.05, n = 17. c The inward current elicited by 100 μM BzATP can be blocked by 10 μM BBG