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. 2011 Mar 14;286(17):15608–15617. doi: 10.1074/jbc.M111.229559

FIGURE 4.

FIGURE 4.

Inhibition of the flop isoform of GluA2Q or GluA2Qflop by AF44/AF42. A, AF44/AF42 inhibited the closed-channel conformation of Glu2AQflop expressed in HEK-293 cells. The left panel is the whole-cell current response to 100 μm glutamate, whereas the right panel is the whole-cell current to the same glutamate concentration but in the presence of 6.25 μm AF44/AF42. B, the inhibition of the open-channel conformation of GluA2Qflop by AF44/AF42 was assayed at 3 mm glutamate. Shown are two representative whole-cell current traces in the absence (left panel) and presence (right panel) of 6.25 μm AF44/AF42.