FIGURE 1.

PCDH12 localization in human placenta. Human 12-week placenta was cryosectioned and immunolabeled with anti-PCDH12 Cter antibody and observed at low magnification (A) or high magnification (B, C). Syncytiotrophoblasts (arrows) and villous cytotrophoblasts (arrowheads) exhibited strong labeling at the cell membrane. Extravillous cytotrophoblasts (evt) showed rather diffuse staining, whereas intravillous vessels (v) harbored only occasional staining. Controls with secondary antibody alone yielded no signals (data not shown). ivs, intervillous space.