TABLE 3.
Genes differentially expressed in the mutants
Genes differentially expressed in the Δgrx2, Δprx1 and Δgrx2/Δprx1 mutants relative to WT, classified by the mutant where they show expression changes and by cellular processes they are involved in. An underlined name indicates that the gene also changes in the double mutant. Genes in the last two columns are those that show changes only in the double mutant.
| Process | Δgrx2-specific genes |
Δprx1-specific genes |
Δgrx2/Δprx1-specific genes |
|||
|---|---|---|---|---|---|---|
| Up | Down | Up | Down | Up | Down | |
| Biosynthesis | BTN2, GAD1, TPK1 | ALD5, ARG1, BAT1, GDH1, ILV3, ILV5, INO2, LEU1, LEU4, MET13, OAC1, PUT1, SNZ1, YEH1 | CAR2, GCV2, LPP1 | BAR1, BAT1, BNA1, GDH1, INO2, LEU1, LEU4, MET13, OAC1, PUT1, RIB4 | MUP3 | MET6 |
| Transcription | NOP1, RTC3 | CIN5, NRG1 | ASG1, DED1, MNP1, MRM1, NOP1, PHO89, SOH1, TRM11, TUF1, VTS1 | CIN5, DAN1, GAT2, NRG1, RPL41A, SRB2 | PHD1 | |
| Iron regulon | FRE7 | FIT3,aFRE4,bICT1, IZH1 | ARN1, ARN2, CCC2, COT1, FET3, FET4, FET5, FIT1, FIT2, FIT3, FRE1, FTR1 | FRE4,bISU1 | ||
| Energy Metabolism | ATP2, GLK1, HXK1, HXT4, NDI1, PNC1, UGP1 | MAE1, MIG2, NCE103 | ACO1, ACO2, ATP12, CIT2, DLD3, GLK1, GSP2, HXK1, HXT4, IDH2, SIT1, TIS11 | NCE103 | ||
| Cell wall | GLC3, GSY1, GSY2, PGM2, SOL4, SPI1, TPS1, TPS2, TSL1, YGP1 | DAN3, MUM3, TIR 4 | AMS1, DAN1, DSE1, DSE4, GLC3, GSC2, ROX1, TIR1, TIR4 | AGA2, GAS2 | CBF2 | |
| Transport | COX5B, GYP7, TPO4 | AGP1, GAP1, YLR348C | AUS1, EGT2, PDR5, VID24 | AGP1, PDR12, STE6, TPO2, TPO3, TPO4, WSC4 | PIC2, SEO1 | |
| Degradation/Proteases | LAP4, PBI2, SNF8 | ATG3, LAP4 | CLB1 | |||
| Other | CMK2, FMP48, IRC9, ISF1, MSC1, PYK2, OPI10, STF2, YAK1, YBR056W, YER067W, YKR093W, YJL44W, YLR345W, YPC1, YPL014W | PAU1, PAU5, YBR012C, YCL021W, YCLX10C, YER074W, YGR035C, YIR042C, YKR075C, YLR348C, YLR349W, YNL024C, YOR225W, YPR157W | MATAα1, MAM33, MF(a)2, PYK2, SAG1, SDS23, SRP40, SSC1, STE3, YDL124W, YDL241W, YER067W, YER074W, YFR006W, YGR079W, YKL177W, YKR093W, YLR041W, YMR317W | MFA2, STE2, YBL029W, YCL021W, YCLX10C, YCR097WB, YCR102C, YGL041C, YIR035C, YLR132C, YLR257W, YNL024C, YPR157W, YRO2 | EMI2, RCN2, YLR194C | |
a FIT3 is down-regulated in Δgrx2 and up-regulated in Δprx1 and Δgrx2/Δprx1.
b FRE4 is down-regulated in all strains.