FIGURE 7.

Schematic diagram of MCT-1-dependent NF-κB activation and NOX-2 expression. IL-1β immediately activates the NF-κB pathway, which may be involved in the expression of NOS-2. On the other hand, IL-1β augments the production of lactate, which causes generation of ROS in an MCT-1-dependent manner. ROS in turn induce late phase activation of NF-κB, which is required for expression of NOX-2. ROS participate in late phase activation of NF-κB. In our previous report (7), we found that IL-1β-induced cell death required augmented production of both NO and ROS. In the present study, the participation of NOX-2 in cell death was indicated.