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. 2010 Nov 29;286(17):15428–15439. doi: 10.1074/jbc.M110.185058

FIGURE 4.

FIGURE 4.

Inhibition of PKC activity with GÖ6976 protects against FeCl3-induced carotid arterial thrombosis. A, representative tracings of carotid blood flow in response to FeCl3 injury after tail vein injection of 1 mg/kg GÖ6976. Values for average initial and postinjury blood flow are shown for representative mice. B, mean initial blood flow rates for A2+/+ (mean ± S.E.; n = 11 for saline, n = 13 for GÖ6976) and A2−/− mice (mean ± S.E., n = 10). C, average cumulative blood flow following arterial occlusion over a 30-min period, calculated as the area under the flow curve, for A2+/+ (mean ± S.E.; n = 11 for saline, n = 13 for GÖ6976) and A2−/− mice (mean ± S.E.; n = 10). *, p < 0.01 GÖ6976 versus saline of A2+/+ mice.