FIGURE 1.

Structures of the chelators used and microarray data showing that DFO and Dp44mT significantly alter the expression of a large number of genes involved in the MAPK signaling transduction pathway. A, chemical structures of DFO and Dp44mT. B, functional pathway annotation of genes significantly altered (p < 0.05) by DFO (250 μm) or Dp44mT (25 μm) after a 24 h/37 °C incubation of DMS-53 lung cancer cells as assessed by a human genome gene array (Affymetrix U133 plus 2.0 array). Only genes with a greater than log₂ value of 1.0 as compared with the control were included in the analysis. Genes in the category of cellular processes (C) and environmental information processing (D) were further sub-categorized according to their functions. E, various signaling transduction pathways affected. Lists of genes were assessed using DAVID. Pathway annotation was obtained through the public data base, KEGG pathway mapping.