Table I.
AA | AC | CC | AC+CC | AA vs AC+CC | |||||
---|---|---|---|---|---|---|---|---|---|
Characteristic | N | % | N | % | N | % | N | % | P |
Total | 229 | 179 | 49 | 228 | |||||
Age: median & range (yrs) | 10.5 | (0.15 – 20.9) | 10.0 | (0.01 – 19.8) | 9.6 | (0.13 – 18.4) | 10.0 | (0.01 – 19.8) | 0.61 |
WBC: median & range Study | 18,900 | (300 – 860,000) | 19,600 | (1,000 – 600,000) | 25,500 | (1,500 – 324,000) | 20,800 | (1,000 – 600,000) | 0.61 |
CCG-2941 | 13 | 6 | 18 | 10 | 7 | 14 | 25 | 11 | 0.06 |
CCG-2961 | 216 | 94 | 161 | 90 | 42 | 86 | 203 | 89 | |
Gender | |||||||||
Male | 130 | 57 | 96 | 54 | 25 | 51 | 121 | 53 | 0.48 |
Female | 99 | 43 | 83 | 46 | 24 | 49 | 107 | 47 | |
Race | |||||||||
White | 129 | 57 | 142 | 79 | 41 | 84 | 183 | 80 | <0.001 |
Black | 33 | 14 | 5 | 3 | 1 | 2 | 6 | 3 | <0.001 |
Hispanic | 42 | 18 | 23 | 13 | 7 | 14 | 30 | 13 | 0.16 |
Asian | 11 | 5 | 3 | 2 | 0 | 0 | 3 | 1 | 0.06 |
Other | 13 | 6 | 6 | 3 | 0 | 0 | 6 | 3 | 0.16 |
Unknown | 1 | 0 | 0 | 0 | |||||
FAB subtype | |||||||||
M0 | 8 | 4 | 13 | 7 | 4 | 8 | 17 | 8 | 0.10 |
M1 | 32 | 14 | 35 | 20 | 4 | 8 | 39 | 17 | 0.43 |
M2 | 67 | 29 | 48 | 27 | 16 | 33 | 64 | 28 | 0.86 |
M4 | 63 | 28 | 45 | 25 | 11 | 22 | 0.54 | ||
56 | 25 | ||||||||
M5 | 40 | 17 | 29 | 16 | 8 | 16 | 37 | 16 | 0.82 |
M6 | 7 | 3 | 2 | 1 | 1 | 2 | 3 | 1 | 0.34 |
M7 | 7 | 3 | 4 | 2 | 5 | 10 | 9 | 4 | 0.79 |
De novo (NOS) | 5 | 2 | 3 | 2 | 0 | 0 | 3 | 1 | 0.72 |
Cytogenetics | |||||||||
Normal | 32 | 23 | 24 | 22 | 10 | 34 | 34 | 25 | 0.92 |
t(8;21) | 27 | 20 | 16 | 15 | 3 | 10 | 19 | 14 | 0.25 |
Abn 16 | 14 | 10 | 9 | 8 | 4 | 14 | 13 | 9 | 0.98 |
Abn 11 | 27 | 20 | 25 | 23 | 5 | 17 | 30 | 22 | 0.79 |
t(6;9) | 1 | 1 | 4 | 4 | 0 | 0 | 4 | 3 | 0.37 |
−7/7- | 4 | 3 | 4 | 4 | 0 | 0 | 4 | 3 | 1.000 |
−5/5- | 2 | 2 | 1 | 1 | 1 | 3 | 2 | 1 | 1.000 |
+8 | 7 | 5 | 9 | 8 | 2 | 7 | 11 | 8 | 0.47 |
+21 | 0 | 0 | 2 | 2 | 0 | 0 | 2 | 1 | 0.50 |
Pseudodiploid | 16 | 12 | 9 | 8 | 4 | 14 | 13 | 9 | 0.68 |
Hyperdiploid | 5 | 4 | 3 | 3 | 0 | 0 | 3 | 2 | 0.50 |
Hypodiploid | 2 | 2 | 3 | 3 | 0 | 0 | 3 | 2 | 1.000 |
Unknown | 92 | 40 | 70 | 39 | 20 | 41 | 90 | 39 | |
Response at end of first course | |||||||||
Remission | 196 | 87 | 147 | 87 | 45 | 92 | 192 | 88 | 0.87 |
Failure | 19 | 8 | 10 | 6 | 2 | 4 | 12 | 6 | 0.31 |
Death | 10 | 4 | 12 | 7 | 2 | 4 | 14 | 6 | 0.48 |
Inevaluable | 4 | 10 | 0 | 10 |