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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Expert Opin Drug Discov. 2011 Feb;6(2):185–193. doi: 10.1517/17460441.2011.547468

Figure 3. A relatively ineffective theoretical partial agonist can have a profound effect on the activity of a theoretical full agonist.

Figure 3

The activity of these ligands resembles the activity of wild-type NRG2β (full agonist) and NRG2β/Q43L (partial agonist). (A) Increasing concentrations of a relatively ineffective theoretical partial agonist almost completely abrogate the activity of a fixed concentration of a theoretical full agonist. (B) The antagonistic effects of a fixed concentration of a relatively effective theoretical partial agonist can be overcome by increasing concentrations of a theoretical full agonist. The resulting rightward shift in the full agonist dose response curve in the presence of the partial agonist is indicative of competitive inhibition of full agonist activity by the partial agonist.