Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2012 Apr 28.

Published in final edited form as: J Med Chem. 2011 Mar 21;54(8):2891–2901. doi: 10.1021/jm101642g

Scheme 1 — Synthesis of 2′-fluoro-6-substituted nucleosides. Reagents: (a) DAST, Pyridine, CH₂Cl_2, 40°C, overnight; (b) LDA, THF, −70°C followed by I₂ or ClCO₂Et; (c) NBS, NaN₃, 1,2-dimethoxyethane, rt, overnight; (d) NaCN, DMF, overnight, rt; (e) 1N NaOH, rt, 1 h; (f) NaN₃, DMF; (g) NaCN, DMF, μW @ 150°C, 5 min.