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. Author manuscript; available in PMC: 2012 Apr 28.
Published in final edited form as: J Med Chem. 2011 Mar 21;54(8):2891–2901. doi: 10.1021/jm101642g

Table 4.

Antimalarial and anticancer activities of 2′-fluoro-6-substituted nucleosides (expressed as IC50 in μM).

Compound IC50 (μM)
AML-1 Pf (3D7) CHO
Chloroquine - 0.022 ± 0.002 -
6-I-uridine21 - 6.2 ± 0.7 366 ± 45
517 6.1 - -
27 > 50 >6000 1363 ± 278
28 >50 >1000 >2000
29 > 50 >1000 >600
30 > 50 >2000 >1000
31 > 50 1090 ± 59 >1000