Figure 4.
Platelet levels alter BF in ischemic limbs. Platelets were depleted or infused in mice directly after hindlimb ischemia surgery. BF was monitored by Doppler for 2 weeks postoperatively in mice injected with PBS (PBS Control) or 3 × 109 platelets (PLT Infusion) or rat IgG (IgG Control) or rat anti–mouse GPIbα (PLT Depletion). (A) Doppler values are represented as mean BF ± SEM for control (dashed line) and treated (solid line) animals (n = 5). *P < .05 vs control (Student t test). **P < .01 vs control (Student t test). ***P < .005 vs control (Student t test). (B) Representative Doppler images over the experimental time course are depicted. The color scale represents the BF values.