Table 1.
Nonsynonymous variation in rat IgG subclass Fc region
| Immunoglobulin Subclass | GenBank Accession Number | Rat Genome (BN) versus GenBank Sequence (PVG) | SHR-A3 versus GenBank Sequence (PVG) | SHR-B2 versus GenBank Sequence (PVG) |
|---|---|---|---|---|
| IgG-1 | M28670 | 0 | 3 | 3 |
| IgG-2a | M28669 | 0 | 7 | 1 |
| IgG-2b | M28671 | 0 | 19 | 2 |
| IgG-2c | X07189 | 0 | 3 | 4 |
| Kabat Position | GenBank (PVG) | Rat Genome (BN) | SHR-A3 | SHR-B2 |
| IgG-1 | ||||
| 195 | Pro | Pro | Pro | Ser |
| 196a | Thr | Thr | Ala | Ala |
| 202 | Val | Val | Ile | Val |
| 359 | Thr | Thr | Ile | Ile |
| IgG-2a | ||||
| 195 | Ser | Ser | Pro | Pro |
| 202 | Val | Val | Ile | Val |
| 234 | Gly | Gly | Val | Gly |
| 235 | Ser | Ser | Pro | Ser |
| 236 | Glu | Glu | Asp | Glu |
| 237 | Val | Val | Ile | Val |
| IgG-2b | ||||
| 162 | Ala | Ala | Pro | Ala |
| 188 | Val | |||
| 189 | Pro | |||
| 215 | Val | Val | Ile | Val |
| 221 | Ile | Ile | Ile | Asn |
| 221a | Gly | Gly | Glu | Gly |
| 221b | His | His | Pro | His |
| 223 | Pro | |||
| 224 | Cys | Cys | Ile | Cys |
| 231 | Val | Val | Ala | Val |
| 361 | Gln | Gln | Lys | Gln |
| 362 | Thr | Thr | Ala | Thr |
| 364 | Ser | Ser | Ile | Ser |
| 369 | Thr | Thr | Ile | Thr |
| 370 | Ser | Ser | Thr | Ser |
| 371 | Gly | Gly | Asp | Gly |
| 376 | Asp | Asp | Asn | Asp |
| 387 | His | His | Arg | Arg |
| 422 | Pro | Pro | Ser | Pro |
| 435 | His | His | Arg | His |
| Kabat Position | GenBank (AO/LOU) | Rat Genome (BN) | SHR-A3 | SHR-B2 |
| IgG-2c | ||||
| 160 | Ser | Ser | Ser | Tyr |
| 210 | Asn | Asn | Asn | Asp |
| 250 | Ile | Ile | Thr | Thr |
| 282 | Val | Val | Val | Ile |
| 351 | Ile | Ile | Phe | Ile |
| 375 | Ala | Ala | Pro | Ala |
Rat genome sequence is derived from the Brown-Norway strain, cDNA sequences are from the PVG strain and an AO/LOU hybrid rat cell line.