Figure 1.

Increased TK activity, decreased serum ROS and protein fluorescence, and increased urine proteine fluorescence in animals with BF treatment. Increased blood TK activity was observable in uremic rats receiving BF for 12 weeks (A). Treatment with BF resulted in a higher tissue activity of TK in the peritoneum and in the kidney (A and B). Uremic rats developed higher levels of serum ROS compared with Sham rats. PD treatment accentuates the generation of ROS in uremic rats (C). Serum protein fluorescence as a marker for systemic protein glycation was increased in uremic animals and was escalated when PD treatment was performed but was ameliorated when BF was substituted, presumably because rats treated with BF excreted a higher amount of glycated protein via the urine (D). All results represent mean ± SEM of 12 animals per group. ***P < 0.001 versus Sham, *P < 0.05 versus Sham, ^§§§P < 0.001 versus SNX, ^§§P < 0.01 versus SNX, ^§P < 0.05 versus SNX, ^$$P < 0.01 versus SNX intraperitoneal, ^$P < 0.05 versus SNX intraperitoneal, ^###P < 0.001 versus SNX+PD, ^##P < 0.01 versus SNX+PD, ^#P < 0.05 versus SNX+PD.