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. 2011 May;22(5):914–926. doi: 10.1681/ASN.2010070750

Figure 3.

Figure 3.

Reduced peritoneal thickening, fibrosis and EMT in rats with BF treatment. In comparison to Sham rats, uremic rats demonstrated a thickening of the peritoneal membrane that is most enhanced when PD treatment was performed. A substitution of BF reduced the thickening of the membrane (A), apparent in the representative photographs of the peritoneal Sirius Red staining (B). As a marker of ongoing fibrosis, TGFβ1 was evaluated and displayed similar results—an enhancement because of uremia and a reduction when BF was given (C). Similar results were obtainable for the staining for αSMA as a marker for EMT (D). All results represent mean ± SEM of 12 animals per group; light microscopy of Sirius Red magnification = 400×. ***P < 0.001 versus Sham, **P < 0.01 versus Sham, §§§P < 0.001 versus SNX, §P < 0.05 versus SNX, $$$P < 0.001 versus SNX intraperitoneal, $$P < 0.01 versus SNX intraperitoneal, ###P < 0.001 versus SNX+PD, #P < 0.05 versus SNX+PD.