Figure 4.

Diminished peritoneal neovascularization in animals treated with BF. SNX rats developed a significantly increased number of peritoneal vessels compared with Sham rats. BF treatment attenuated peritoneal neovascularization that was most pronounced in PD treatment (A). To confirm these results, staining for VEGF was performed and resulted in similar observations (B). For determination of inflammatory peritoneal formation, staining for IL-6 was performed and CD3-positive leukocytes were counted. Analog results demonstrated an increase of peritoneal inflammation because of uremia that was most present in uremic animals treated with PD and was less apparent when BF was substituted (C and D). All results represent mean ± SEM of 12 animals per group. ***P < 0.001 versus Sham, *P < 0.05 versus Sham, ^§§P < 0.01 versus SNX, ^§P < 0.05 versus SNX, ^$$$P < 0.001 versus SNX intraperitoneal, ^$$P < 0.01 versus SNX intraperitoneal, ^$P < 0.05 versus SNX intraperitoneal, ^#P < 0.05 versus SNX+PD.