Figure 6.

Increased morphologic kidney damage in animals not receiving BF. To obtain substantial damage of the remnant kidney in the SNX model, different established scores describing glomerular and tubular changes were estimated using PAS stained cross sections (A). SNX rats revealed an increased GSI (B), an elevated TII (C), and a larger tubulointerstitial area (D) compared with Sham animals. A treatment with BF alleviated glomerular sclerosis and tubular injury. PD treatment aggravated glomerular and tubular damage but was attenuated because of BF treatment (B through D). All results represent mean ± SEM of 12 animals per group; light microscopy of PAS staining magnification = 400×. ***P < 0.001 versus Sham, *P < 0.05 versus Sham, ^§§P < 0.01 versus SNX, ^§P < 0.05 versus SNX, ^$P < 0.05 versus SNX intraperitoneal, ^##P < 0.01 versus SNX+PD, ^#P < 0.05 versus SNX+PD.