Figure 7.

Decreased glomerular expression of AGE and RAGE in BF treated rats. One possible mechanism of ongoing kidney damage during PD treatment is mediated via the interaction of AGE and RAGE. To clarify this, we performed glomerular and tubular quantification of the expression of CML and RAGE. The tubular expression of CML and RAGE (A and B) was increased in uremic rats in comparison to Sham animals without any difference between the treatment groups, whereas the glomerular staining for CML and RAGE reflected decreased expression of both when BF was substituted (A and B). All results represent mean ± SEM of 12 animals per group. ***P < 0.001 versus Sham, **P < 0.01 versus Sham, *P < 0.05 versus Sham, ^§P < 0.05 versus SNX, ^$$P < 0.01 versus SNX intraperitoneal, ^$P < 0.05 versus SNX intraperitoneal, ^#P < 0.05 versus SNX+PD.