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. 2011 May;22(5):914–926. doi: 10.1681/ASN.2010070750

Figure 8.

Figure 8.

Pronounced fibrosis in rats not receiving BF. Tubulointerstitial fibrosis is the common phenotype of every kidney disease. The SNX model results in an ongoing tubulointerstitial fibrosis, representatively displayed in panel A (Sirius Red staining of the tubulointerstitium of the uremic groups). As a marker of proceeding fibrosis, the glomerular and tubular expression of TGFβ1 was evaluated (B). In comparison to Sham animals, SNX rats showed enhanced glomerular and tubular expression of TGFβ1 that was alleviated when BF was given. Similar results were obtained in the comparison of uremic rats treated with PD versus SNX rats treated with PD and BF (B). All results represent mean ± SEM of 12 animals per group; light microscopy of Sirius Red magnification = 400×. ***P < 0.001 versus Sham, *P < 0.05 versus Sham, §P < 0.05 versus SNX, $$P < 0.01 versus SNX intraperitoneal, $P < 0.05 versus SNX intraperitoneal, #P < 0.05 versus SNX+PD.