Table 3.
Multiple linear regression analysis of measured GFR and cardiovascular risk factors
| Independent Variable | Model 1. Adjusted for Age, Gender, Use of ACE Inhibitors or ARBs |
Model 2. As Model 1 and Adjusted for All Other Independent Variables Except Systolic BP |
||||
|---|---|---|---|---|---|---|
| Estimate (ml/min per 1.73 m2) | (95% CI) | P | Estimate (ml/min per 1.73 m2) | (95% CI) | P | |
| First degree relative with MI < 60 years (yes/no) | −0.57 | (−2.24 to 1.09) | 0.50 | −0.51 | (−2.16 to 1.14) | 0.54 |
| Physically active versus inactive | −1.57 | (−2.91 to −0.23) | 0.02 | −1.06 | (−2.43 to 0.30) | 0.13 |
| Current smoking versus not smoking | 3.37 | (1.75 to 4.98) | <0.0001 | 2.87 | (1.18 to 4.56) | <0.0001 |
| Body mass index per SD increasea | −0.13 | (−0.81 to 0.55) | 0.71 | −0.87 | (−1.80 to 0.06) | 0.07 |
| Systolic BP per SD increase | −0.56 | (−1.27 to 0.14) | 0.12 | |||
| Diastolic BP per SD increase | −1.03 | (−1.73 to −0.34) | 0.003 | −0.94 | (−1.67 to −0.21) | 0.01 |
| LDL cholesterol per SD increase | −0.30 | (−0.96 to 0.36) | 0.38 | −0.27 | (−0.96 to 0.43) | 0.45 |
| HDL cholesterol per SD increaseb | −0.01 | (−0.72 to 0.70) | 0.98 | −1.04 | (−2.09 to 0.01) | 0.05 |
| Triglycerides per SD increase | 0.13 | (−0.55 to 0.80) | 0.72 | 0.31 | (−0.49 to 1.10) | 0.45 |
ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; CI, confidence intervals.
aSignificant gender interaction for body mass index: Female, estimate = −0.87, P = 0.07. Male, estimate = 1.93, P = 0.002.
bSignificant gender interaction for HDL cholesterol: Female, estimate −1.04, P = 0.05. Male, estimate = 1.79, P = 0.003.