Table 4.

Multiple linear regression analyses of association between estimates of GFRs and cardiovascular risk factors

Dependent Variable	Independent Variable	Model 1. Adjusted for Age, Gender, Use of Angiotensin Converting Enzyme Inhibitors or Angiotensin Receptor Blockers			Model 2. As Model 1 and Adjusted for Measured GFR			Model 3. As Model 2 and Adjusted for All Other Independent Variables Except Systolic BP
		Estimate (ml/min per 1.73 m2)	(95% CI)	P	Estimate (ml/min per 1.73 m2)	(95% CI)	P	Estimate (ml/min per 1.73 m2)	(95% CI)	P
MDRD equation	First degree relative with MI < 60 years (yes/no)	−2.18	(−4.18 to −0.18)	0.03	−1.81	(−3.48 to −0.13)	0.03	−1.75	(−3.41 to −0.08)	0.04
	Physically active versus inactive	−2.66	(−4.27 to −1.06)	<0.0001	−1.63	(−2.98 to −0.29)	0.02	−1.03	(−2.41 to 0.34)	0.14
	Current smoking versus not smoking	6.54	(4.61 to 8.46)	<0.0001	4.36	(2.73 to 5.99)	<0.001	3.87	(2.15 to 5.58)	<0.0001
	Body mass index per SD increase	−0.70	(−1.52 to 0.12)	0.09	−0.61	(−1.30 to 0.07)	0.08	−0.26	(−1.02 to 0.51)	0.51
	Systolic BP per SD increase	−0.91	(−1.76 to −0.07)	0.03	−0.54	(−1.25 to 0.17)	0.13
	Diastolic BP per SD increase	−1.70	(−2.54 to −0.87)	<0.0001	−1.03	(−1.73 to −0.32)	<0.001	−0.62	(−1.36 to 0.12)	0.10
	LDL cholesterol per SD increase	−0.30	(−1.10 to 0.50)	0.46	−0.10	(−0.77 to 0.57)	0.77	0.06	(−0.64 to 0.76)	0.86
	HDL cholesterol per SD increase	0.15	(−0.71 to 1.00)	0.73	0.15	(−0.56 to 0.87)	0.68	0.06	(−0.77 to 0.89)	0.89
	Triglycerides per SD increase	−0.14	(−0.95 to 0.68)	0.74	−0.22	(−0.90 to 0.46)	0.53	−0.20	(−0.99 to 0.60)	0.63
CKD-EPI equation	First degree relative with MI < 60 years (yes/no)	−1.16	(−2.28 to −0.04)	0.04	−0.95	(−1.89 to −0.01)	0.047	−0.92	(−1.85 to 0.02)	0.06
	Physically active versus inactive	−1.33	(−2.22 to −0.43)	<0.0001	−0.76	(−1.52 to 0.00)	0.050	−0.53	(−1.30 to 0.25)	0.18
	Current smoking versus not smoking	3.10	(2.02 to 4.18)	<0.0001	1.90	(0.98 to 2.81)	<0.001	1.63	(0.67 to 2.59)	<0.0001
	Body mass index per SD increase	−0.44	(−0.90 to 0.02)	0.06	−0.39	(−0.78 to −0.01)	0.046	−0.21	(−0.64 to 0.22)	0.33
	Systolic BP per SD increase	−0.54	(−1.02 to −0.07)	0.02	−0.34	(−0.74 to 0.06)	0.09
	Diastolic BP per SD increase	−0.91	(−1.38 to −0.45)	<0.0001	−0.54	(−0.94 to −0.15)	0.01	−0.33	(−0.74 to 0.09)	0.13
	LDL cholesterol per SD increase	−0.20	(−0.65 to 0.25)	0.38	−0.09	(−0.47 to 0.28)	0.63	0.02	(−0.37 to 0.42)	0.91
	HDL cholesterol per SD increase	0.12	(−0.35 to 0.60)	0.61	0.13	(−0.27 to 0.53)	0.53	0.01	(−0.46 to 0.47)	0.98
	Triglycerides per SD increase	−0.16	(−0.61 to 0.29)	0.49	−0.21	(−0.59 to 0.18)	0.29	−0.16	(−0.61 to 0.28)	0.47
Rule's cystatin C equation	First degree relative with MI < 60 years (yes/no)	−0.30	(−2.33 to 1.74)	0.78	0.08	(−1.64 to 1.80)	0.93	0.36	(−1.23 to 1.95)	0.66
	Physically active versus inactive	1.44	(−0.20 to 3.08)	0.08	2.47	(1.09 to 3.86)	<0.001	0.04	(−1.27 to 1.36)	0.95
	Current smoking versus not smoking	−6.56	(−8.52 to −4.60)	<0.0001	−8.85	(−10.48 to −7.22)	<0.001	−8.94	(−10.58 to −7.30)	<0.0001
	Body mass index per SD increase	−3.35	(−4.17 to −2.53)	<0.0001	−3.26	(−3.95 to −2.57)	<0.001	−2.81	(−3.54 to −2.08)	<0.0001
	Systolic BP per SD increase	−0.33	(−1.20 to 0.53)	0.45	0.04	(−0.69 to 0.77)	0.92
	Diastolic BP per SD increase	−0.81	(−1.66 to 0.05)	0.06	−0.13	(−0.86 to 0.59)	0.72	0.32	(−0.39 to 1.03)	0.37
	LDL cholesterol per SD increase	−1.31	(−2.12 to −0.50)	<0.0001	−1.11	(−1.80 to −0.43)	<0.001	0.00	(−0.67 to 0.66)	0.99
	HDL cholesterol per SD increase	3.53	(2.68 to 4.39)	<0.0001	3.54	(2.82 to 4.25)	<0.001	1.63	(0.83 to 2.42)	<0.0001
	Triglycerides per SD increase	−3.00	(−3.82 to −2.19)	<0.0001	−3.09	(−3.77 to −2.40)	<0.001	−1.29	(−2.06 to −0.53)	0.001

Each row gives the estimates of the regression coefficients from three different models where the dependent variable is given in the first column and the independent variable in the second. Each of the three models was adjusted for different covariates, as indicated in the column headings. CI, confidence interval.