Table 2.
Association between preoperative statin use and outcomes
| No. of Patients with Event (Statin Use) |
No. of Events per 10,000 Patients (Statin Use) |
Odds Ratio (95% Confidence Interval) |
||||
|---|---|---|---|---|---|---|
| No | Yes | No | Yes | Unadjusted | Adjusteda | |
| Acute kidney injury | 2355 | 1665 | 162 | 245 | 1.53 (1.43, 1.63) | 0.84 (0.78, 0.90) |
| Acute dialysis | 681 | 492 | 47 | 72 | 1.55 (1.38, 1.74) | 0.83 (0.72, 0.95) |
| Death | 4448 | 1526 | 306 | 225 | 0.73 (0.69, 0.77) | 0.79 (0.74, 0.85) |
A total of 67,941 patients were taking a statin before surgery, and 145,406 were not.
aAdjusted for age (per year), gender, rural location, the number of distinct drug products in the preceding year (≤5, 6 to 10, 11 to 15, 16 to 20, 21 to 26, >26), socioeconomic status (quintiles of neighborhood income), cerebrovascular disease, chronic kidney disease, diabetes, coronary artery disease, congestive heart failure, angiotensin-converting enzyme inhibitor use, angiotensin receptor blocker use, β-blocker use, non–potassium-sparing diuretic use, calcium channel blocker use, number of primary care visits in the preceding 3 years (0, 1 to 3, 4 to 10, >10), number of cholesterol tests in the preceding 3 years (0, 1, 2, ≥3), ≥1 cardiac stress test in the preceding 3 years, ≥1 echocardiogram in the preceding 3 years, ≥1 carotid ultrasound in the preceding 3 years, type of surgery (cardiac, thoracic, vascular, abdominal, retroperitoneal), and the year of surgery (per year).