Table 2.
Major GO categories of human O-GlcNAcylated proteins.
| Gene Ontology (GO) Terms | Count* | % Total | P-Value |
|---|---|---|---|
| GO Biological Processes | |||
| GO:0045449~regulation of transcription | 108 | 23.48 | 5.90E-04 |
| GO:0006350~transcription | 93 | 20.22 | 1.99E-04 |
| GO:0051252~regulation of RNA metabolic process | 75 | 16.30 | 6.09E-03 |
| GO:0006355~regulation of transcription, DNA-dependent | 69 | 15.00 | 3.08E-02 |
| GO:0043933~macromolecular complex subunit organization | 54 | 11.74 | 1.64E-09 |
| GO:0065003~macromolecular complex assembly | 53 | 11.52 | 4.68E-10 |
| GO:0046907~intracellular transport | 52 | 11.30 | 8.96E-10 |
| GO:0007049~cell cycle | 52 | 11.30 | 2.14E-07 |
| GO:0006412~translation | 51 | 11.09 | 3.30E-21 |
| GO:0006396~RNA processing | 51 | 11.09 | 4.00E-12 |
| GO:0008104~protein localization | 51 | 11.09 | 1.91E-05 |
| GO:0010605~negative regulation of macromolecule metabolic process | 48 | 10.43 | 1.39E-06 |
| GO:0042981~regulation of apoptosis | 48 | 10.43 | 1.60E-05 |
| GO:0043067~regulation of programmed cell death | 48 | 10.43 | 2.07E-05 |
| GO:0010941~regulation of cell death | 48 | 10.43 | 2.25E-05 |
| GO:0045184~establishment of protein localization | 47 | 10.22 | 1.11E-05 |
| GO:0010604~positive regulation of macromolecule metabolic process | 47 | 10.22 | 1.55E-04 |
| GO Molecular Function | |||
| GO:0000166~nucleotide binding | 132 | 28.70 | 2.56E-13 |
| GO:0003677~DNA binding | 101 | 21.96 | 7.11E-04 |
| GO:0032555~purine ribonucleotide binding | 92 | 20.00 | 7.02E-06 |
| GO:0032553~ribonucleotide binding | 92 | 20.00 | 7.02E-06 |
| GO:0017076~purine nucleotide binding | 92 | 20.00 | 3.91E-05 |
| GO:0030528~transcription regulator activity | 83 | 18.04 | 6.87E-07 |
| GO:0003723~RNA binding | 82 | 17.83 | 2.05E-24 |
| GO:0001882~nucleoside binding | 82 | 17.83 | 1.56E-05 |
| GO:0005524~ATP binding | 81 | 17.61 | 1.03E-06 |
| GO:0032559~adenyl ribonucleotide binding | 81 | 17.61 | 1.73E-06 |
| GO:0030554~adenyl nucleotide binding | 81 | 17.61 | 1.26E-05 |
| GO:0001883~purine nucleoside binding | 81 | 17.61 | 2.16E-05 |
| GO:0005198~structural molecule activity | 56 | 12.17 | 8.96E-12 |
| GO:0042802~identical protein binding | 51 | 11.09 | 3.27E-09 |
| GO Cellular Component | |||
| GO:0043232~intracellular non-membrane-bounded organelle | 170 | 36.96 | 6.37E-29 |
| GO:0043228~non-membrane-bounded organelle | 170 | 36.96 | 6.37E-29 |
| GO:0005829~cytosol | 141 | 30.65 | 7.16E-46 |
| GO:0031974~membrane-enclosed lumen | 131 | 28.48 | 6.60E-24 |
| GO:0043233~organelle lumen | 129 | 28.04 | 1.20E-23 |
| GO:0070013~intracellular organelle lumen | 128 | 27.83 | 5.00E-24 |
| GO:0031981~nuclear lumen | 116 | 25.22 | 2.44E-25 |
| GO:0005856~cytoskeleton | 77 | 16.74 | 2.21E-08 |
| GO:0005654~nucleoplasm | 77 | 16.74 | 2.07E-18 |
| GO:0030529~ribonucleoprotein complex | 72 | 15.65 | 3.55E-29 |
| GO:0005730~nucleolus | 55 | 11.96 | 3.09E-11 |
| GO:0000267~cell fraction | 49 | 10.65 | 2.01E-03 |
| GO:0044430~cytoskeletal part | 49 | 10.65 | 1.16E-04 |
* The table is sorted based on counts of proteins annotated with given GO terms in each of the major GO category. The percentage of proteins with given GO terms over total number of human O-GlcNAcylated proteins is shown (% Total). A more detailed GO profiles are shown in [Additional file 1, Supplementary Table S1].