Table 5.
The comparisons of EORTC QLQ-C30 and H&N35 scales for head and neck cancer survivors at different tumor sites
| Nasopharynx (n = 316) |
Oral cavity (n = 129) |
Oropharynx (n = 75) |
Hypropharynx &Larynx(n = 120) |
||
|---|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | p | |
| EORTC QLQ-C30 | |||||
| Global quality of life | 53.7 (20.4) | 56.1 (16.7) | 55.2 (21.6) | 54.8 (20.9) | NS |
| Physical functioning | 85.7 (16.3) | 86.4 (13.8)e | 82.2 (16.9) | 80.9 (18.7)c | 0.015 |
| Role functioning | 88.7 (19.5) | 87.0 (19.1) | 83.6 (22.1) | 81.2 (25.0)c | <0.01 |
| Emotional functioning | 78.0 (19.7) | 79.9 (18.6) | 75.3 (22.7) | 77.0 (20.8) | NS |
| Cognitive functioning | 77.8 (18.7) | 82.8 (19.2)d | 75.1 (23.0) | 76.9 (20.9) | 0.025 |
| Social functioning | 77.0 (23.2) | 75.4 (22.8) | 73.1 (27.0) | 71.0 (25.8) | NS |
| Fatigue | 29.6 (19.8) | 24.9 (21.2)d | 32.7 (19.2) | 30.4 (21.4) | 0.037 |
| Nausea/Vomiting | 8.4 (15.6) | 6.2 (14.2)d, e | 13.5 (22.5) | 12.4 (20.8) | <0.01 |
| Pain | 20.8 (21.5) | 19.2 (23.1) | 26.8 (21.9) | 24.9 (23.8) | 0.038 |
| Dyspnea | 12.7 (19.9) | 12.4 (20.4)e | 17.8 (23.5) | 23.6 (24.0)c | <0.01 |
| Insomnia | 25.1 (26.3) | 23.1 (25.5) | 30.1 (22.8) | 30.7 (26.5) | 0.049 |
| Appetite loss | 17.0 (23.8) | 17.9 (24.3)d | 30.7 (26.0)b | 23.1 (24.1) | <0.01 |
| Constipation | 16.5 (22.4) | 18.4 (22.4) | 23.7 (26.8) | 24.0 (25.3)c | <0.01 |
| Diarrhea | 13.4 (18.9) | 12.2 (18.6) | 16.4 (26.0) | 15.9 (19.3) | NS |
| Financial problems | 23.4 (26.4) | 26.9 (25.7) | 31.9 (29.9) | 30.5 (27.9) | 0.023 |
| EORTC QLQ-HN35 | |||||
| Pain | 17.0 (18.3) | 17.3 (22.9)d | 27.4 (20.7)b | 21.5 (22.5) | <0.01 |
| Swallowing | 26.8 (22.4) | 30.6 (25.4) | 38.0 (23.6)b | 33.8 (27.5)c | <0.01 |
| Senses (taste/smell) | 27.2 (27.0) | 22.1 (26.8) | 26.4 (27.4) | 31.3 (30.1) | NS |
| Speech | 23.0 (23.3) | 25.6 (21.8)e | 32.0 (27.1)b | 41.3 (30.7)c | <0.01 |
| Social eating | 24.1 (24.9) | 33.2 (27.0)a | 35.4 (27.8)b | 30.7 (29.5) | <0.01 |
| Social contact | 15.4 (19.9) | 24.0 (23.2)a | 23.9 (26.7)b | 27.5 (27.4)c | <0.01 |
| Sexuality | 23.8 (27.6) | 24.3 (24.4) | 30.5 (29.4) | 31.3 (29.5) | 0.035 |
| Teeth | 38.1 (28.3) | 41.0(31.8) | 42.7 (30.2) | 36.1 (31.3) | NS |
| Opening mouth | 30.1 (29.7) | 43.9 (34.2)a, e | 37.8 (32.9)f | 25.1 (29.4) | <0.01 |
| Dry mouth | 53.5 (31.3) | 45.9 (30.7) | 49.2 (30.6)f | 36.6 (27.5)c | <0.01 |
| Sticky saliva | 42.8 (31.7) | 37.6 (28.4) | 46.3 (29.8) | 35.0 (29.8) | 0.024 |
| Coughing | 25.9 (23.9) | 23.9 (23.3)e | 31.5 (27.4)f | 43.1 (25.4)c | <0.01 |
| Feeling ill | 29.6 (25.5) | 24.8 (23.7) | 31.5 (25.1) | 32.1 (26.0) | NS |
a : p < 0.05, Oral cavity compared with Nasopharynx; b : p < 0.05, Oropharynx compared with Nasopharynx; c : p < 0.05, Hypropharynx & Larynx compared with Nasopharynx; d : p < 0.05, Oral cavity compared with Oropharynx; e : p < 0.05, Oral cavity compared with Hypropharynx & Larynx; f : p < 0.05, Oropharynx compared with Hypropharynx & Larynx