Figure 5. Selective inhibition of serine protease proteolytic activity by SFTI-FCQR Asn₁₄.

Examination of fibrinogen proteolysis by trypsin and kallikreins by SDS-PAGE. Bands were visualised with Coomassie blue staining after resolving on 10% polyacrylamide gels. Images are representative of three separate experiments. Inhibition of KLK4 proteolytic activity by (A) SFTI-FCQR Asp₁₄ and (B) SFTI-FCQR Asn₁₄. Inhibition of trypsin proteolytic activity by (C) SFTI-1 and (D) SFTI-FCQR Asn₁₄. Inhibition of proteolytic activity of (F) KLK12 and (F) KLK14 by SFTI-FCQR Asn₁₄.