Table 2.
Genes selected for the set-based analysis from previous published reports. We note that evidence for these genes is not confined to these reports.
| Gene ID | Chr | Associated Phenotype | Sample/s | Reference |
|---|---|---|---|---|
| OPRD1 | 1 | substance dependence | CT | Zhang et al, 2008 |
| POMC | 2 | opioid dependence in alcoholic families | COGA,CT | Xuei et al, 2007; Zhang et al, 2009 |
| GAD1 | 2 | initial sensitivity; age of onset of AD | IR | Kuo et al, 2009 |
| PECR | 2 | AD (GWAS) | TR | Treutlein et al, 2009 |
| ERC2 | 3 | AD (GWAS) | TR | Treutlein et al, 2009 |
| GABRG1 | 4 | AD | CT | Covault et al, 2008 |
| GABRA2 | 4 | AD; conduct disorder, antisocial disorder | COGA | Edenberg et al, 2004; Dick et al, 2006 |
| SNCA | 4 | Craving | COGA | Foroud et al, 2007 |
| ADH5 | 4 | AD | CT,IR | Luo et al, 2006; Kuo et al, 2009 |
| ADH4 | 4 | AD | COGA,CT,IR | Edenberg et al, 2006; Luo et al, 2007; Kuo et al, 2009 |
| ADH1A | 4 | AD | COGA,CT,IR | Edenberg et al, 2006; Luo et al, 2007; Kuo et al, 2009 |
| ADH1B | 4 | AD | COGA,CT,IR | Edenberg et al, 2006; Luo et al, 2007; Kuo et al, 2009 |
| ADH1C | 4 | AD (GWAS) | TR,IR | Treutlein et al, 2009 |
| ADH7 | 4 | AD | CT | Luo et al, 2007 |
| NFKB1 | 4 | AD | COGA | Edenberg et al, 2008 |
| TACR3 | 4 | AD and cocaine dependence | COGA | Foroud et al, 2008 |
| DKK2 | 4 | AD symptom counts | IR | Kalsi et al, 2010 |
| EGF | 4 | AD symptom counts | IR | Kalsi et al, 2010 |
| CAST | 5 | AD (GWAS) | TR | Treutlein et al, 2009 |
| ERAP1 | 5 | AD (GWAS) | TR | Treutlein et al, 2009 |
| PCDHA1-13 | 5 | AD (GWAS) | TR | Treutlein et al, 2009 |
| PPP2R2B | 5 | AD (GWAS) | TR | Treutlein et al, 2009 |
| GABRA1 | 5 | Drinking patterns | GOGA | Dick et al, 2006 |
| CNR1 | 6 | AD and drug dependence | CT | Zuo et al, 2007 |
| GABRR1 | 6 | AD | COGA | Xuei et al, 2010 |
| GABRR2 | 6 | AS | COGA | Xuei et al, 2010 |
| ESR1 | 6 | AD (GWAS) | TR | Treutlein et al, 2009 |
| OPRM1 | 6 | AD and drug dependence | CT | Zhang et al, 2006 |
| NPY | 7 | AD | CT | Lappalainen et al, 2002 |
| ACN9 | 7 | AD | COGA | Dick et al, 2008 |
| CHRM2 | 7 | AD, Major depressive disorder, illicit drugs | COGA | Wang et al, 2004; Luo et al, 2005 |
| GATA4 | 8 | AD (GWAS) | TR | Treutlein et al, 2009 |
| OPRK1 | 8 | AD | COGA,CT | Xuei et al, 2006; Zhang et al, 2008 |
| PENK | 8 | opioid dependence | COGA | Xuei et al, 2007 |
| NCAM1 | 11 | AD | CT | Yang et al, 2007 |
| TTC12 | 11 | AD | CT | Yang et al, 2007 |
| ANKK1 | 11 | AD | COGA,CT | Dick et al, 2007; Yang et al, 2007 |
| DRD2 | 11 | AD | COGA,CT | Dick et al, 2007; Yang et al, 2007 |
| CCDC41 | 12 | AD (GWAS) | TR | Treutlein et al, 2009 |
| ALDH2 | 12 | AD | CT,IR | Luo et al, 2006; Kuo et al, 2009 |
| GABRG3 | 15 | AD | COGA | Dick et al, 2004 |
| CHRNA5 | 15 | AD | COGA | Wang et al, 2009 |
| CDH13 | 16 | AD (GWAS) | TR | Treutlein et al, 2009 |
| ZNF699 | 19 | AD | IR | Riley et al, 2006 |
| CD3EAP | 19 | AD (GWAS) | TR | Treutlein et al, 2009 |
| PDYN | 20 | AD | COGA | Xuei et al, 2006 |
| OPRL1 | 20 | opioid dependence | COGA | Xuei et al, 2007 |
| GRIK1 | 21 | AD | CT | Kranzler et al, 2009 |