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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Eur J Immunol. 2011 Mar 21;41(5):1321–1333. doi: 10.1002/eji.201040730

Figure 8.

Figure 8

Systemic inflammation influences the quantity and quality of 2° memory CD8+ T cells. (A) Experimental setup: 1° memory OT-I cells (1 × 104) were injected into naïve Thy1.2 mice prior to immunization with OVA-peptide pulsed DCs. One group of mice was coinfected with att LM. (B) Percentage of 2° memory OT-I cells in indicated lymphoid organs and tertiary tissues 28 days post-immunization. (C) The phenotype (CD27 and KLRG-1) of OT-I cells in the spleen. (D) Total number of cytokine- (IFN-γ, TNF, and IL-2) and granzyme B-producing OT-I cells in the spleen after direct ex vivo OVA257–264-peptide stimulation. (B–D) Data show mean+SD (n = 5 mice/group).