Table 3.

Regions activated in the nicotine vs placebo contrast

Region (Harvard-Oxford, maximum probability)	MNI coordinates of local maxima (X, Y, Z)			Maximum Z value
Middle frontal gyrus (R)	30	16	32	3.83
Middle frontal gyrus (L)	−54	16	38	2.94
ACC (R)	2	24	34	3.09
Frontal orbital cortex (R)	32	20	−24	3.86
Frontal orbital cortex (L)	−42	30	−4	2.34
Pre-central gyrus (R)	50	−6	34	2.78
Pre-central gyrus (L)	−60	8	34	3.8
Lateral occipital cortex (L)	−24	−64	50	3.64
Frontal pole (R)	30	50	−16	2.82

Whole-brain voxelwise analysis (N = 39, smokers and non-smokers, cluster-corrected at Z = 2.3, p = 0.05)