Table 7. Example table: multivariate association between demographic, environmental and genetic risk factors and progression to advanced age-related macular degeneration (AMD).
| Regression coefficient (βi) | OR (95% CI)a | P | |
|---|---|---|---|
| Intercept (α) | −5.780 | ||
| Age (years) | |||
| ≤70 | 0 | 1.0 | |
| >70 | 0.4116 | 1.5 (1.1–2.0) | 0.008 |
| Sex | |||
| Female | 0 | 1.0 | |
| Male | 0.0688 | 1.1 (0.8–1.5) | 0.68 |
| Education | |||
| ≤High school | 0 | 1.0 | |
| >High school | −0.1280 | 0.9 (0.6–1.2) | 0.42 |
| Baseline grade | |||
| 2 | 0 | 1.0 | |
| 3 | 2.3944 | 11.0 (5.3–22.8) | <0.001 |
| 4 | 2.9521 | 19.1 (8.9–41.2) | <0.001 |
| Smoking | |||
| Never | 0 | 1.0 | |
| Past | 0.1211 | 1.1 (0.8–1.6) | 0.47 |
| Current | 1.1261 | 3.1 (1.7–5.6) | <0.001 |
| BMI | |||
| <25 | 0 | 1.0 | |
| 25–29 | 0.5170 | 1.7 (1.2–2.4) | 0.006 |
| 30+ | 0.4754 | 1.6 (1.1–2.4) | 0.024 |
| Treatment group | |||
| Placebo | 0 | 1.0 | |
| Antioxidants | −0.1299 | 0.9 (0.6–1.3) | 0.54 |
| Zinc | −0.3897 | 0.7 (0.4–1.0) | 0.075 |
| Antioxidants and zinc | −0.4973 | 0.6 (0.4–0.9) | 0.023 |
| rs1061170 | |||
| TT | 0 | 1.0 | |
| CT | 0.2644 | 1.3 (0.8–2.1) | 0.29 |
| CC | 0.6778 | 2.0 (1.1–3.5) | 0.019 |
| P trend | 0.014 | ||
| rs10490924 | |||
| GG | 0 | 1.00 | |
| GT | 0.8396 | 2.3 (1.6–3.3) | <0.001 |
| TT | 1.3837 | 4.0 (2.6–6.1) | <0.001 |
| P trend | <0.001 | ||
| rs1410996 | |||
| TT | 0 | 1.0 | |
| CT | 0.5251 | 1.7 (0.7–4.0) | 0.23 |
| CC | 0.8606 | 2.4 (1.0–5.8) | 0.061 |
| P trend | 0.029 | ||
| rs9332739 | |||
| GG | 0 | 1.0 | |
| CG/CC | −1.0510 | 0.4 (0.2–0.8) | 0.010 |
| rs641153 | |||
| CC | 0 | 1.0 | |
| CT or TT | −0.2147 | 0.8 (0.5–1.4) | 0.42 |
| rs2230199 | |||
| CC | 0 | 1.0 | |
| CG | 0.3679 | 1.4 (1.1–2.0) | 0.022 |
| GG | 0.5970 | 1.8 (1.0–3.2) | 0.044 |
| P trend | 0.006 | ||
Adapted from ref. 6.
a
ORs adjusted for age (<70, ≥70), sex, education (≤high school, >high school), smoking (never, past, current), baseline AMD grade, BMI (<25, 25–29, 30+) and treatment groups (placebo, antioxidants, zinc and antioxidants plus zinc), and all six genetic variants and associated genotypes as listed in the table. Calculation of the AMD progression risk Score=α+βiXi, where i refers to each of the variables listed.