Table 1.

Cytotoxic effect of diterpenes isolated from P. elisabethae (SW Caribbean) in human cancer cell lines (HeLa, PC-3, HCT116, MCF-7) and normal BJ cells.

Compounds	GI50 ± S.E (μM)
	HeLa	PC-3	HCT116	MCF7	BJ
PsG	9.22 ± 0.45	8.83 ± 0.54	12.04 ± 0.36	9.42 ± 0.43	7.62 ± 0.38
PsP	10.31 ± 0.49	13.77 ± 0.58	17.89 ± 0.45	12.58 ± 0.45	10.40 ± 0.42
PsQ	5.82 ± 0.33	7.81 ± 0.35	7.66 ± 0.27	8.44 ± 0.41	4.47 ± 0.31
PsS	13.79 ± 0.39	52.05 ± 0.31	33.50 ± 0.33	26.25 ± 0.45	29.14 ± 0.45
PsT	14.58 ± 0.35	21.99 ± 0.46	24.24 ± 0.42	14.72 ± 0.46	12.94 ± 0.37
PsU	15.63 ± 0.32	24.81 ± 0.34	23.44 ± 0.40	26.46 ± 0.46	9.35 ± 0.34
3-O-Ac-PsU	44.61 ± 0.35	26.45 ± 0.31	20.48 ± 0.48	83.93 ± 0.39	62.03 ± 0.45
seco-PsJ	21.08 ± 0.37	37.21 ± 0.41	31.68 ± 0.32	28.02 ± 0.51	15.00 ± 0.35
seco-PsK	15.83 ± 0.18	13.57 ± 0.38	13.28 ± 0.27	11.45 ± 0.36	8.28 ± 0.29
IMNGD*	11.20 ± 0.15	12.11 ± 0.20	19.90 ± 0.19	9.67 ± 0.15	7.91 ± 0.17
Staurosporine**	105.6 ± 0.41	61.82 ± 0.38	45.56 ± 0.45	176.6 ± 0.38	13.56 ± 0.35

^*GI₅₀ (μg/mL),

^**GI₅₀ (nM)