Table 2.
Antibacterial activity of diterpenes isolated from P. elisabethae (SW Caribbean) in two Gram-positive bacteria.
Compounds |
IC50 ± S.E (μM) * |
|
---|---|---|
S. aureus | E. faecalis | |
PsG | 4.48 ± 0.18 | 3.14 ± 0.22 |
PsP | 14.91 ± 0.20 | 37.35 ± 0.29 |
PsQ | 3.30 ± 0.20 | 7.38 ± 0.16 |
PsS | 3.89 ± 0.23 | 20.20 ± 0.25 |
PsT | 5.39 ± 0.25 | 4.38 ± 0.16 |
PsU | 2.97 ± 0.17 | 3.19 ± 0.25 |
3-O-Ac-PsU | 20.23 ± 0.19 | 7.64 ± 0.16 |
seco-PsJ | 6.52 ± 0.12 | 4.08 ± 0.19 |
seco-PsK | 4.20 ± 0.16 | 3.82 ± 0.21 |
IMNGD** | 2.33 ± 0.09 | 3.47 ± 0.15 |
Penicillin G | 1.61 ± 0.08 | - |
Vancomycin | - | 4.21 ± 0.11 |
All compounds evaluated were inactive against the Gram-negative bacterium P. aeruginosa and the yeast C. albicans.
IC50 (μg/mL).