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. 2011 Jan 31;12(2):1009–1029. doi: 10.3390/ijms12021009

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Proposed model of HA, CD44 and versican interactions between ovarian cancer and peritoneal cells. The formation of a stabilized HA/versican pericellular matrix surrounding ovarian cancer cells increases motility and protects the ovarian cancer cells against the mechanical forces in the peritoneal cavity and enable ovarian cancer cells to strongly adhere to CD44 expressed on peritoneal cells. This allows subsequent ovarian cancer invasion and peritoneal dissemination. From Ween et al. [26].