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. 2011 Feb 10;12(2):1115–1132. doi: 10.3390/ijms12021115

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Anti-inflammatory activity of the VK₂ and VK₃ intermediates toward TPA-induced edema on mouse ear. Each compound (250 μg, gray bar; and 500 μg, black bar) was applied individually to one ear of a mouse, and after 30 min TPA (0.5 μg) was applied to both ears. Edema was evaluated after 7 h. The inhibitory effect is expressed as the percentage of edema. Data are shown as the means ± SE (n = 6). ** P < 0.01 and * P < 0.05 versus controls.