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. 2011 Feb 22;12(2):1334–1358. doi: 10.3390/ijms12021334

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© 2011 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Claudin 4 expression in ovarian cancer subtypes in tissue microarrays. (A) Claudin 4 is differentially expressed in ovarian cancer subtypes (p = 0.0026). Percent of TMA cases positive for claudin 4 staining in ovarian cancer subtypes. Staining score: black, score +1 (<10% of cancer cells staining); white, score +2 (10–50% of cancer cells staining); gray, score +3 (>50% of cancer cells staining). (B) Claudin 4 expression by Silverberg Grade. Percent of TMA cases positive for claudin 4 by Silverberg Grade (grade 1 is black; grade 2 is diagonal stripe; grade 3 is gray). Positive scores (1, 2, and 3) were binarized. Claudin 4 expression is significantly lower in high grade endometrioid ovarian cancer (p = 0.0178). (C) Percent of TMA cases positive for claudin 4 by stage (stage I is black; stage II is diagonal stripe; stage III is gray). Positive scores (1, 2, and 3) were binarized. Claudin 4 expression was not significantly different between the stages.